Mutation by Substitution Welcome! You are encouraged to register with the site and login (for free). When you register, you support the site and your question history is saved.Whereas in genetic mutation by insertion extra base pairs are inserted into the DNA, in mutation by substitution one base in the sequence is replaced for another. Whereas in genetic mutation by insertion extra base pairs are inserted into the DNA, in mutation by substitution one base in the sequence is replaced for another. Whereas in genetic mutation by insertion extra base pairs are inserted into the DNA, mutation by substitution occurs when one base in the sequence is replaced for another. Unlike genetic mutation by insertion, where extra base pairs are inserted into the DNA, one base in the sequence is replaced for another in mutation by substitution. Unlike genetic mutation by insertion, where extra base pairs are inserted into the DNA, mutation by substitution replaces one base in the sequence with another. Unlike the case of extra base pairs inserted into the DNA, which is genetic mutation by insertion, in mutation by substitution one base in the sequence is replaced with another. Review Answer